Investigating the Allosteric Regulation of YfiN from Pseudomonas aeruginosa: Clues from the Structure of the Catalytic Domain

@inproceedings{Giardina2013InvestigatingTA,
  title={Investigating the Allosteric Regulation of YfiN from Pseudomonas aeruginosa: Clues from the Structure of the Catalytic Domain},
  author={Giorgio Giardina and Alessandro Paiardini and Silvia Fernicola and Stefano Franceschini and Serena Rinaldo and Valentina Stelitano and Francesca Cutruzzol{\`a}},
  booktitle={PloS one},
  year={2013}
}
Pseudomonas aeruginosa is responsible for a plethora of biofilm mediated chronic infections among which cystic fibrosis pneumonia is the most frightening. The long-term survival strategy of P. aeruginosa in the patients lungs is based on a fine balance of virulence vs dormant states and on genetic adaptation, in order to select persistent phenotypes as the small colony variants (SCVs), which strongly correlate with antibiotic resistance and poor lung function. Recent studies have coupled SCV… CONTINUE READING