Investigating signs of recent evolution in the pool of proviral HIV type 1 DNA during years of successful HAART.

@article{Mens2007InvestigatingSO,
  title={Investigating signs of recent evolution in the pool of proviral HIV type 1 DNA during years of successful HAART.},
  author={Helene Mens and Anders Gorm Pedersen and Louise Bruun J\orgensen and St{\'e}phane Hu{\'e} and Yizi Yang and Jan Gerstoft and Terese Lea Katzenstein},
  journal={AIDS research and human retroviruses},
  year={2007},
  volume={23 1},
  pages={107-15}
}
In order to shed light on the nature of the persistent reservoir of human immunodeficiency virus type 1 (HIV-1), we investigated signs of recent evolution in the pool of proviral DNA in patients on successful HAART. Pro-viral DNA, corresponding to the C2-V3-C3 region of the HIV-1 env gene, was collected from PBMCs isolated from 57 patients. Both "consensus" (57 patients) and clonal (7 patients) sequences were obtained from five time points spanning a 24-month period. The main computational… CONTINUE READING

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