Investigating protein isoforms via proteomics: a feasibility study.

@article{Blakeley2010InvestigatingPI,
  title={Investigating protein isoforms via proteomics: a feasibility study.},
  author={Paul Blakeley and Jennifer A. Siepen and Craig Lawless and Simon J. Hubbard},
  journal={Proteomics},
  year={2010},
  volume={10 6},
  pages={1127-40}
}
Alternative splicing (AS) and processing of pre-messenger RNAs explains the discrepancy between the number of genes and proteome complexity in multicellular eukaryotic organisms. However, relatively few alternative protein isoforms have been experimentally identified, particularly at the protein level. In this study, we assess the ability of proteomics to inform on differently spliced protein isoforms in human and four other model eukaryotes. The number of Ensembl-annotated genes for which… CONTINUE READING

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