Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein.

@article{Aleksic2007InvestigatingPH,
  title={Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein.},
  author={Maja Aleksic and Camilla K Smith Pease and David A Basketter and Maria Panico and Howard R. Morris and Anne Dell},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2007},
  volume={21 4},
  pages={723-33}
}
Covalent modification of skin proteins by electrophiles is a key event in the induction of skin sensitisation but not skin irritation although the exact nature of the binding mechanisms has not been determined empirically for the vast majority of sensitisers. It is also unknown whether immunologically relevant protein targets exist in the skin contributing to effecting skin sensitisation. To determine the haptenation mechanism(s) and spectra of amino acid reactivity in an intact protein for two… CONTINUE READING