Investigating metabolite essentiality through genome-scale analysis of Escherichia coli production capabilities

@article{Imielinski2005InvestigatingME,
  title={Investigating metabolite essentiality through genome-scale analysis of Escherichia coli production capabilities},
  author={Marcin Imielinski and Calin Belta and {\'A}d{\'a}m M. Hal{\'a}sz and Harvey Rubin},
  journal={Bioinformatics},
  year={2005},
  volume={21 9},
  pages={2008-16}
}
MOTIVATION A phenotype mechanism is classically derived through the study of a set of mutants and comparison of their biochemical capabilities. One method of comparing mutant capabilities is to characterize producible and knocked out metabolites. However such an effect is difficult to manually assess, especially for a large biochemical network and a complex media. Current algorithmic approaches towards analyzing metabolic networks either do not address this specific property or are… CONTINUE READING

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