Investigating lipid headgroup composition within epithelial membranes: a systematic review.

  title={Investigating lipid headgroup composition within epithelial membranes: a systematic review.},
  author={R T Coones and Rebecca J. Green and Richard A. Frazier},
  journal={Soft matter},
Membrane lipid composition is often quoted within the literature, but with very little insight into how or why these compositions vary when compared to other biological membranes. One prominent area that lacks understanding in terms of rationale for lipid variability is the human gastro-intestinal tract (GIT). We have carried out a comprehensive systematic literature search to ascertain the key lipid components of epithelial membranes, with a particular focus on addressing the human GIT and to… 

Truncated Pleurocidin Derivative with High Pepsin Hydrolysis Resistance to Combat Multidrug-Resistant Pathogens

Interestingly, GK-4 displays rapid bacteriostatic activity, great stability and low hemolysis, as well as enhanced hydrolytic resistance to pepsin treatment, and is a potential orally available candidate to treat infections caused by multidrug-resistant pathogens.

Recent Advances in Mass Spectrometry-Based Structural Elucidation Techniques

  • Xin Ma
  • Chemistry, Biology
  • 2022
This review aims to focus on the technical advances of MS-based structural elucidation methods over the past five years, and provide an overview of their applications in complex mixture analysis.



Artificial plasma membrane models based on lipidomic profiling.

Altered lipid profile and changes in uroplakin properties of rat urothelial plasma membrane with diets of different lipid composition

A role of the lipids in the establishment of the uroplakin interactions is suggested, and specific dietary fats may have important functional implications.

Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts*

This work will review the evidence that rafts exist in cells and focus on their structure, or the organization of raft lipids and proteins, and the role of rafts in signaling in hematopoietic cells.

Role of Lipid Composition on the Interaction between a Tryptophan-Rich Protein and Model Bacterial Membranes.

Data show distinct differences in the lipid binding behavior of Pin-b as a result of a single residue mutation, highlighting the importance of hydrophobic and charged amino acids in antimicrobial protein and peptide activity.

Phospholipid composition of the mammalian red cell membrane can be rationalized by a superlattice model.

Although the phospholipid composition of the erythrocyte membrane has been studied extensively, it remains an enigma as to how the observed composition arises and is maintained. We show here that the

Membrane lipidome of an epithelial cell line

A shotgun-based lipidomics workflow was developed that enabled the absolute quantification of mammalian membrane lipidomes with minimal sample processing from low sample amounts and investigated the remodeling of the total cell membrane lipidome during the transition from a nonpolarized morphology to an epithelial morphology and vice versa.

Membrane Lipid Composition Plays a Central Role in the Maintenance of Epithelial Cell Adhesion to the Extracellular Matrix

It is demonstrated that phospholipid composition plays an essential role in the in vivo maintenance of FC structures involved in cell-ECM adhesion.