Investigating intracerebral haemorrhage

@article{Wilson2015InvestigatingIH,
  title={Investigating intracerebral haemorrhage},
  author={Duncan Wilson and Matthew E. Adams and F. Robertson and M. Murphy and David John Werring},
  journal={BMJ : British Medical Journal},
  year={2015},
  volume={350}
}
#### The bottom line A 49 year old, right handed woman presented with sudden left upper and lower limb weakness. Examination confirmed left hemiparesis with Medical Research Council (MRC) grade 3/5 power in the upper limb and 0/5 power in the lower limb. She had been diagnosed with relapsing-remitting multiple sclerosis but had been stable (without relapses) for over a year. Computed tomography (CT) on admission revealed a right frontal intracerebral haemorrhage (fig 1A⇓). Fig 1 A: Non… 
Clinical relevance of neuroimaging biomarkers of small vessel disease in relation to intracranial haemorrhage
TLDR
A combination of CTA, SVD and pre-ICH hypertension predict the likelihood of finding a macrovascular cause in patients with acute spontaneous ICH, allowing informed decisions regarding the likely benefit and risk of IADSA.
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Management of acute intracerebral haemorrhage - an update.
TLDR
Evidence shows that outcome can be improved with admission to an acute stroke unit and active care, including urgent reversal of anticoagulant effects and, potentially, intensive blood pressure reduction.
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TLDR
Insights from clinical settings that have led to the development of numerous animal models of spontaneous intracerebral haemorrhage are discussed, and some of the current and future challenges for clinicians to understand ICH are surveyed.
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It is suggested that MB could inhibit apoptosis and ameliorate neuroinflammation after ICH, and its neuroprotective effects might be exerted via the activation of the PI3K/Akt/GSK3β pathway.
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TLDR
The reintroduction of NOACs in patients with atrial fibrillation and previous intracerebral hemorrhage depends on its etiology and should be after about 4-8 weeks if the cardioembolic risk is high and the risk for intracranial hemorrhage small.
Antithrombotic treatment for secondary prevention of stroke and other thromboembolic events in patients with stroke or transient ischemic attack and non-valvular atrial fibrillation: A European Stroke Organisation guideline
TLDR
For patients with atrial fibrillation and ischemic stroke or transient isChemic attack, non-vitamin K antagonist oral anticoagulants are the preferred treatment for secondary prevention of recurrent stroke or thromboembolism.
EGb761 Ameliorates Neuronal Apoptosis and Promotes Angiogenesis in Experimental Intracerebral Hemorrhage via RSK1/GSK3β Pathway
TLDR
EGb761 reduces neuronal apoptosis and promotes angiogenesis in experimental intracerebral hemorrhage via RSK1/GSK3β pathway and is found that mice in EGb 761 group performed better on rotarod test.
Retraction Note to: The Crucial Role of Cyclin-Dependent Kinase-5-Ataxia-Telangiectasia Mutated Axis in ICH-Induced Neuronal Injury of Rat Model
TLDR
It is suggested that ATM could be phosphorylated by CDK5 to induce the active caspase-3 and neuronal injury when intracerebral hemorrhage or ischemia occurred.
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