Investigating hypoxic tumor physiology through gene expression patterns

@article{Denko2003InvestigatingHT,
  title={Investigating hypoxic tumor physiology through gene expression patterns},
  author={Nicholas C. Denko and Lucrezia A Fontana and Karen M. Hudson and Patrick D. Sutphin and Soumya Raychaudhuri and Russ B. Altman and Amato J. Giaccia},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={5907-5914}
}
Clinical evidence shows that tumor hypoxia is an independent prognostic indicator of poor patient outcome. Hypoxic tumors have altered physiologic processes, including increased regions of angiogenesis, increased local invasion, increased distant metastasis and altered apoptotic programs. Since hypoxia is a potent controller of gene expression, identifying hypoxia-regulated genes is a means to investigate the molecular response to hypoxic stress. Traditional experimental approaches have… CONTINUE READING

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