Investigating human disease using stem cell models

@article{Sterneckert2014InvestigatingHD,
  title={Investigating human disease using stem cell models},
  author={Jared Sterneckert and Peter Reinhardt and Hans R. Sch{\"o}ler},
  journal={Nature Reviews Genetics},
  year={2014},
  volume={15},
  pages={625-639}
}
Tractable and accurate disease models are essential for understanding disease pathogenesis and for developing new therapeutics. As stem cells are capable of self-renewal and differentiation, they are ideally suited both for generating these models and for obtaining the large quantities of cells required for drug development and transplantation therapies. Although proof of principle for the use of adult stem cells and embryonic stem cells in disease modelling has been established, induced… CONTINUE READING
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SHOWING 1-10 OF 140 REFERENCES

Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis

  • T Suzuki
  • Am. J. Respir. Crit. Care Med
  • 2014

reversal by gene correction

  • Sanders, L. H. et al. LRRK2 mutations cause mitochondrial DNA patients
  • Neurobiol. Dis. 62, 381–386
  • 2014

A comparative study of Parkinson’s disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism

  • J Trinh
  • Neurobiol. Aging 35,
  • 2013

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