Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes.

@article{Smith2005InvestigatingHI,
  title={Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes.},
  author={Catrin Tudur Smith and Paula R Williamson and A G Marson},
  journal={Statistics in medicine},
  year={2005},
  volume={24 9},
  pages={1307-19}
}
Differences across studies in terms of design features and methodology, clinical procedures, and patient characteristics, are factors that can contribute to variability in the treatment effect between studies in a meta-analysis (statistical heterogeneity). Regression modelling can be used to examine relationships between treatment effect and covariates with the aim of explaining the variability in terms of clinical, methodological, or other factors. Such an investigation can be undertaken using… CONTINUE READING

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