Investigating complexity in systematic reviews of interventions by using a spectrum of methods.

@article{Anderson2013InvestigatingCI,
  title={Investigating complexity in systematic reviews of interventions by using a spectrum of methods.},
  author={Laurie M Anderson and Sandy R Oliver and Susan Michie and Eva Rehfuess and Jane Noyes and Ian Shemilt},
  journal={Journal of clinical epidemiology},
  year={2013},
  volume={66 11},
  pages={1223-9}
}
Systematic reviews framed by PICOS (Populations, Interventions, Comparisons, Outcomes, and Study designs) have been valuable for synthesizing evidence about the effects of interventions. However, this framework is limited in its utility for exploring the influence of variations within populations or interventions, or about the mechanisms of action or causal pathways thought to mediate outcomes, other contextual factors that might similarly moderate outcomes, or how and when these mechanisms and… CONTINUE READING

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