Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase.

@article{Ortiz2009InvestigatingAS,
  title={Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase.},
  author={Jorge G Mu{\~n}iz Ortiz and Robert Opoka and Daniel Kane and Iain L. Cartwright},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2009},
  volume={107 2},
  pages={416-26}
}
Chronic exposure to arsenic-contaminated drinking water can lead to a variety of serious pathological outcomes. However, differential responsiveness within human populations suggests that interindividual genetic variation plays an important role. We are using Drosophila to study toxic metal response pathways because of unrivalled access to varied genetic approaches and significant demonstrable overlap with many aspects of mammalian physiology and disease phenotypes. Genetic analysis (via… CONTINUE READING

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