Investigating apoptosis: characterization and analysis of Trichoplusia ni-caspase-1 through overexpression and RNAi mediated silencing.

@article{Hebert2009InvestigatingAC,
  title={Investigating apoptosis: characterization and analysis of Trichoplusia ni-caspase-1 through overexpression and RNAi mediated silencing.},
  author={Colin G. Hebert and James R. Valdes and William E. Bentley},
  journal={Insect biochemistry and molecular biology},
  year={2009},
  volume={39 2},
  pages={113-24}
}
In both mammals and invertebrates, caspases play a critical role in apoptosis. Although Lepidopteron caspases have been widely studied in Spodoptera frugiperda cells, this is not the case for Trichoplusia ni cells, despite their widespread use for the production of recombinant protein and differences in baculovirus infectivity between the two species. We have cloned, expressed, purified and characterized Tn-caspase-1 in several situations: in its overexpression, in silencing via RNA… CONTINUE READING
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