Investigating antibody-catalyzed ozone generation by human neutrophils.

  title={Investigating antibody-catalyzed ozone generation by human neutrophils.},
  author={Bernard M. Babior and Cindy Takeuchi and Julie M Ruedi and Abel Gutierrez and Paul Wentworth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 6},
Recent studies have suggested that antibodies can catalyze the generation of previously unknown oxidants including dihydrogen trioxide (H(2)O(3)) and ozone (O(3)) from singlet oxygen ((1)O(2)(*)) and water. Given that neutrophils have the potential both to produce (1)O(2)(*) and to bind antibodies, we considered that these cells could be a biological source of O(3). We report here further analytical evidence that antibody-coated neutrophils, after activation, produce an oxidant with the… CONTINUE READING