Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection

  title={Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection},
  author={A. Thomas and C. Laxton and J. Rodman and Nisha Myangar and N. Horscroft and T. Parkinson},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={2969 - 2978}
ABSTRACT Toll-like receptors (TLRs) are key mediators of innate immunity, and their activation by microbial components leads to the production of cytokines and interferons. Recombinant alpha interferon has been used to treat several viral diseases and is the current standard of care for hepatitis C virus (HCV) infection. Recently, agonists of TLR7 and TLR9 have been shown to have clinical efficacy in HCV patients, and this is correlated with their ability to induce endogenous type I interferon… Expand
Tim-3 suppression combined with TLR3 activation enhances antiviral immune response in patients with chronic HCV infection
Impaired Toll-Like Receptor 3-Mediated Immune Responses from Macrophages of Patients Chronically Infected with Hepatitis C Virus
Antiviral applications of Toll-like receptor agonists.
Negative regulation of the type I interferon signaling pathway by synthetic Toll-like receptor 7 ligands.
  • A. Forsbach, C. Müller, +5 authors J. Vollmer
  • Biology, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2012
Characterization of HCV Interactions with Toll-Like Receptors and RIG-I in Liver Cells
Pharmacokinetic-Pharmacodynamic Modeling of Alpha Interferon Response Induced by a Toll-Like 7 Receptor Agonist in Mice


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Interleukin-1 Inhibits Hepatitis C Virus Subgenomic RNA Replication by Activation of Extracellular Regulated Kinase Pathway
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