Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection

@article{Thomas2007InvestigatingTR,
  title={Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection},
  author={A. Thomas and C. Laxton and J. Rodman and Nisha Myangar and N. Horscroft and T. Parkinson},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2007},
  volume={51},
  pages={2969 - 2978}
}
ABSTRACT Toll-like receptors (TLRs) are key mediators of innate immunity, and their activation by microbial components leads to the production of cytokines and interferons. Recombinant alpha interferon has been used to treat several viral diseases and is the current standard of care for hepatitis C virus (HCV) infection. Recently, agonists of TLR7 and TLR9 have been shown to have clinical efficacy in HCV patients, and this is correlated with their ability to induce endogenous type I interferon… Expand
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