Investigating Multimodal Diagnostic Eye Biomarkers of Cognitive Impairment by Measuring Vascular and Neurogenic Changes in the Retina

@article{CabreraDeBuc2018InvestigatingMD,
  title={Investigating Multimodal Diagnostic Eye Biomarkers of Cognitive Impairment by Measuring Vascular and Neurogenic Changes in the Retina},
  author={Delia Cabrera DeBuc and G{\'a}bor M{\'a}rk Somfai and Edmund Arthur and Maja Kostic and Susel Oropesa and Carlos Mendoza Santiesteban},
  journal={Frontiers in Physiology},
  year={2018},
  volume={9}
}
Previous studies have demonstrated that cognitive impairment (CI) is not limited to the brain but also affects the retina. In this pilot study, we investigated the correlation between the retinal vascular complexity and neurodegenerative changes in patients with CI using a low-cost multimodal approach. Quantification of the retinal structure and function were conducted for every subject (n = 69) using advanced retinal imaging, full-field electroretinogram (ERG) and visual performance exams. The… 
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References

SHOWING 1-10 OF 124 REFERENCES
Peripheral Retinal Imaging Biomarkers for Alzheimer’s Disease: A Pilot Study
TLDR
UWF retinal imaging revealed a significant association between AD and peripheral hard drusen formation and changes to the vasculature beyond the posterior pole, at BL and after clinical progression over 2 years, suggesting that monitoring pathological changes in the peripheral retina might become a valuable tool in AD monitoring.
Retinal Vascular Fractals and Cognitive Impairment
TLDR
A sparser retinal microvascular network, represented by reduced arteriolar and venular fractal dimensions, was associated with cognitive impairment, suggesting that early microv vascular damage may be present in preclinical stages of dementia.
Retinal abnormalities in early Alzheimer's disease.
TLDR
The results show that AD produces quantifiable abnormalities in the retina, including a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins.
Structural and functional impairment of the retina and optic nerve in Alzheimer's disease.
TLDR
It is shown that in patients with AD, even without visual failure there was a decrease in macular and RNFL thickness, as well as a decrease of the electrical activity of the macula.
Retinal vascular fractal dimension is associated with cognitive dysfunction.
  • C. CheungS. Ong T. Wong
  • Medicine
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • 2014
Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases.
TLDR
This review shows how the conditions of the retinal microvessels could be used to assess the condition of brain microvessel because the microvascular network of the retina and brain share, in many aspects, standard features in development, morphology, function, and pathophysiology.
Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease
TLDR
Retinal photographic analysis shows potential as an adjunct for early detection of AD or monitoring of AD-progression or response to treatments, and relationships between retinal vascular parameters, neocortical brain amyloid plaque burden and AD are demonstrated.
Quantitative analysis of retinal vessel attenuation in eyes with retinitis pigmentosa.
TLDR
In RP patients, the severity of visual field loss is correlated with retinal vessel attenuation, and quantitative retinal vessels caliber measurement may be a useful additional clinical marker for monitoring progression of RP or potential treatment response.
Alzheimer’s Disease in the Retina: Imaging Retinal Aβ Plaques for Early Diagnosis and Therapy Assessment
TLDR
It is demonstrated that retinal plaques can be individually monitored in real time following glatiramer acetate immunization, indicating that translation of noninvasive retinal-plaque imaging to humans could eventually facilitate early and accurate AD diagnosis and therapy assessment.
...
...