Inverted-U-shaped dopamine actions on human working memory and cognitive control.

  title={Inverted-U-shaped dopamine actions on human working memory and cognitive control.},
  author={Roshan Cools and Mark D'Esposito},
  journal={Biological psychiatry},
  volume={69 12},
Brain dopamine (DA) has long been implicated in cognitive control processes, including working memory. However, the precise role of DA in cognition is not well-understood, partly because there is large variability in the response to dopaminergic drugs both across different behaviors and across different individuals. We review evidence from a series of studies with experimental animals, healthy humans, and patients with Parkinson's disease, which highlight two important factors that contribute… CONTINUE READING
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