Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking.

  title={Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking.},
  author={Albert Gjedde and Yoshitaka Kumakura and Paul Cumming and Jakob Linnet and Arne M\oller},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 8},
Sensation seeking is a core personality trait that declines with age in both men and women, as do also both density and availability of the dopamine D(2/3) receptors in striatum and cortical regions. In contrast, novelty seeking at a given age relates inversely to dopamine receptor availability. The simplest explanation of these findings is an inverted-U-shaped correlation between ratings of sensation seeking on the Zuckerman scale and dopamine D(2/3) receptor availability. To test the claim of… CONTINUE READING


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