Inverted Alu repeats unstable in yeast are excluded from the human genome.

@article{Lobachev2000InvertedAR,
  title={Inverted Alu repeats unstable in yeast are excluded from the human genome.},
  author={Kirill S Lobachev and Judith E. Stenger and Olga Kozyreva and Jerzy Jurka and Dmitry A Gordenin and Michael A. Resnick},
  journal={The EMBO journal},
  year={2000},
  volume={19 14},
  pages={3822-30}
}
The nearly one million ALU: repeats in human chromosomes are a potential threat to genome integrity. ALU:s form dense clusters where they frequently appear as inverted repeats, a sequence motif known to cause DNA rearrangements in model organisms. Using a yeast recombination system, we found that inverted ALU: pairs can be strong initiators of genetic instability. The highly recombinagenic potential of inverted ALU: pairs was dependent on the distance between the repeats and the level of… CONTINUE READING

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