Inversion events in the HSV-1 genome are directly mediated by the viral DNA replication machinery and lack sequence specificity.

@article{Weber1988InversionEI,
  title={Inversion events in the HSV-1 genome are directly mediated by the viral DNA replication machinery and lack sequence specificity.},
  author={Peter C. Weber and Mark D Challberg and Nancy J Nelson and Michael Levine and Joseph Charles Glorioso},
  journal={Cell},
  year={1988},
  volume={54 3},
  pages={369-81}
}
The bacterial transposable element Tn5 was observed to undergo high-frequency sequence inversion when integrated into the herpes simplex virus type 1 (HSV-1) genome. Deletion analysis of the IS50 elements through which this recombination event occurred demonstrated the absence of cis-acting signals involved in the inversion process. Several observations suggested an intimate association of the recombination mechanism with HSV-1 DNA replication, including the ability of the seven viral genes… CONTINUE READING

From This Paper

Topics from this paper.
23 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Similar Papers

Loading similar papers…