Inverse system perturbations as a new methodology for identifying transcriptomic signaling participants in balanced biological processes.

@article{Hauser2009InverseSP,
  title={Inverse system perturbations as a new methodology for identifying transcriptomic signaling participants in balanced biological processes.},
  author={Kai Hauser and Amir Hossein Abdollahi and Peter E Huber},
  journal={Cell cycle},
  year={2009},
  volume={8 17},
  pages={2718-22}
}
We devise a novel, systems-biology approach for identifying genetic participants in homeostatic biological processes. The central idea is that genes which are inversely regulated in alignment with positive and negative system perturbation are strong candidates for significant regulatory involvement in a given homeostatic process. This allows us to integrate known genetic participants together with hitherto unknown ones into a signaling network. We illustrate this concept and justify the… CONTINUE READING

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