Inverse relationship between thalamic and orbitofrontal volumes in obsessive-compulsive disorder.

@article{Rotge2009InverseRB,
  title={Inverse relationship between thalamic and orbitofrontal volumes in obsessive-compulsive disorder.},
  author={J Y Rotge and Bixente Dilharreguy and Bruno Aouizerate and Corinne Martin-Guehl and Dominique Guehl and Nematollah Jaafari and Nicolas Langbour and Bernard H Bioulac and Jean Tignol and Mich{\`e}le Allard and Pierre Burbaud},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2009},
  volume={33 4},
  pages={682-7}
}
Volumetric magnetic resonance imaging (MRI) studies in obsessive-compulsive disorder (OCD) have reported a smaller volume of the orbitofrontal cortex (OFC) and a larger volume of the thalamus compared with healthy controls. Both of these brain regions are strongly connected; therefore, it may be hypothesized that cortical and thalamic alterations are related. Here, we investigated the relationship between thalamic and orbitofrontal volumes in OCD patients relative to healthy controls. MRI… CONTINUE READING