Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling

@article{BenAbu2009InverseCI,
  title={Inverse coupling in leak and voltage-activated K+ channel gates underlies distinct roles in electrical signaling},
  author={Yuval Ben-Abu and Yufeng Zhou and N. V. Zilberberg and Ofer Yifrach},
  journal={Nature Structural &Molecular Biology},
  year={2009},
  volume={16},
  pages={71-79}
}
Voltage-activated (Kv) and leak (K2P) K+ channels have key, yet distinct, roles in electrical signaling in the nervous system. Here we examine how differences in the operation of the activation and slow inactivation pore gates of Kv and K2P channels underlie their unique roles in electrical signaling. We report that (i) leak K+ channels possess a lower activation gate, (ii) the activation gate is an important determinant controlling the conformational stability of the K+ channel pore, (iii) the… CONTINUE READING

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