Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines.

@article{Halatsch2004InverseCO,
  title={Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines.},
  author={M E Halatsch and Esther E Gehrke and Vassilios I. Vougioukas and Ingolf Carl B{\"o}tef{\"u}r and Farhad A-Borhani and Thomas H Efferth and Erich Gebhart and Sebastian Domhof and Ursula Schmidt and Michael Buchfelder},
  journal={Journal of neurosurgery},
  year={2004},
  volume={100 3},
  pages={523-33}
}
OBJECT Quantitative and qualitative alterations in the epidermal growth factor receptor (EGFR) commonly occur in many cancers in humans, including malignant gliomas. The aim of the current study was to evaluate molecular and cellular effects of OSI-774, a novel EGFR tyrosine kinase inhibitor, on nine glioblastoma multiforme (GBM) cell lines. METHODS The effects of OSI-774 on expression of EGFR messenger (m)RNA and protein, proliferation, anchorage-independent growth, and apoptosis were… CONTINUE READING

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