Inverse correlation between p 53 protein levels and DNA repair efficiency in human fibroblast strains treated with 4-nitroquinoline 1-oxide : evidence that lesions other than DNA strand breaks trigger the p 53 response

@inproceedings{Mirzayans1999InverseCB,
  title={Inverse correlation between p 53 protein levels and DNA repair efficiency in human fibroblast strains treated with 4-nitroquinoline 1-oxide : evidence that lesions other than DNA strand breaks trigger the p 53 response},
  author={Razmik Mirzayans and Saber Bashir and David Murray and Malcolm C. Paterson},
  year={1999}
}
Ionizing radiation-induced stabilization and the resultant transient accumulation of the p53 tumor suppressor protein is impaired in cells from ataxia telangiectasia (AT) patients, indicating a key role for ATM, the gene mutated in AT, upstream in the radiation-responsive p53 signaling pathway. Activation of this pathway is generally assumed to be triggered by DNA strand breaks produced directly following genotoxic stress or indirectly during excision repair of DNA lesions. The aim of this… CONTINUE READING

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P 53 protein exhibits 3 9 - to - 5 9 exonuclease activity

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