Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice

  title={Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice},
  author={Shogo Matsuyama and Rie Teraoka and Hiroshi Mori and Takami Tomiyama},
Soluble amyloid &bgr; peptide (A&bgr;) is believed to cause synaptic dysfunction in the early stages of Alzheimer's disease. Here, we examined in-vivo synaptic functions in the hippocampus in two lines of transgenic mice expressing different amounts of human wild-type amyloid precursor protein (APP). Compared with nontransgenic littermates, one transgenic line with higher APP expression displayed potent inhibition of paired-pulse facilitation and long-term potentiation in the absence of amyloid… 
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