Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status.

@article{Yanagawa2011InverseCB,
  title={Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status.},
  author={Naoki Yanagawa and Gen Tamura and Hiroyuki Oizumi and Makoto Endoh and Mitsuaki Sadahiro and Teiichi Motoyama},
  journal={Anticancer research},
  year={2011},
  volume={31 4},
  pages={1211-4}
}
BACKGROUND Epidemiological studies have demonstrated a causal link between tobacco smoking and lung cancer. However, lung adenocarcinoma (AC) is also frequently found in non-smokers compared with other non-small cell lung carcinoma (NSCLC) subtypes. MATERIALS AND METHODS Mutations of both epithelial growth factor receptor (EGFR) and KRAS, and the methylation status of 10 tumor suppressor or tumor-related genes were examined in 62 ACs, and the relationship with smoking status, and the… CONTINUE READING
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