Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus.

@article{Lee2006InverseCB,
  title={Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus.},
  author={Jyh-Hong Lee and L H Wang and Y C Lin and Yao-Hsu Yang and D Lin and Bor-Luen Chiang},
  journal={Immunology},
  year={2006},
  volume={117 2},
  pages={280-6}
}
CD4(+) CD25(+) regulatory T cells (Tregs) are critical in maintaining self-tolerance and preventing organ-specific autoimmunity. Their role in paediatric systemic lupus erythematosus (SLE), an autoimmune disease characterized by inappropriate regulation of hyperactivated B and T cells, has not been clearly defined. Using flow cytometry to determine cell populations and real-time polymerase chain reaction to assay mRNA expression for FOXP3, CTLA-4, and GITR, we characterized CD4(+) CD25(+) T… CONTINUE READING

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