Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder

@inproceedings{Liu2016InverseCI,
  title={Inverse changes in L1 retrotransposons between blood and brain in major depressive disorder},
  author={Shu Liu and Tingfu Du and Zeyue Liu and Yan Shen and Jianbo Xiu and Qi Xu},
  booktitle={Scientific reports},
  year={2016}
}
Long interspersed nuclear element-1 (LINE-1 or L1) is a type of retrotransposons comprising 17% of the human and mouse genome, and has been found to be associated with several types of neurological disorders. Previous post-mortem brain studies reveal increased L1 copy number in the prefrontal cortex from schizophrenia patients. However, whether L1 retrotransposition occurs similarly in major depressive disorder (MDD) is unknown. Here, L1 copy number was measured by quantitative PCR analysis in… CONTINUE READING
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