Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression.

@article{Mizuguchi2012InverseAA,
  title={Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression.},
  author={Hiroyuki Mizuguchi and Shohei Ono and Masashi Hattori and Hiroyuki Fukui},
  journal={Journal of pharmacological sciences},
  year={2012},
  volume={118 1},
  pages={117-21}
}
Histamine H(1) receptor (H1R) expression influences the severity of allergy symptoms. We examined the effect of inverse agonists on H1R gene expression. Two inverse agonists (carebastine and mepyramine), but not the neutral antagonist oxatomide, decreased inositol phosphate accumulation. The inverse agonists also decreased H1R gene expression and down… CONTINUE READING