Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.

  title={Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.},
  author={Denis J. Dupr{\'e} and Christian Le Gouill and Denis Gingras and Marek Rola-Pleszczynski and Jana Stankova},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={309 1},
Cysteinyl leukotrienes (CysLTs) are associated with several inflammatory processes, including asthma. Due to this association, considerable effort has been invested in the development of antagonists to the CysLT receptors (CysLT(1)R). Many of these molecules have been shown to specifically interact with CysLT(1)R, but little is known about their impact on the conformation of the receptor and its activity. We were especially interested in possible inverse agonist activity of the antagonists… CONTINUE READING


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