Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?

Abstract

Inverse agonism has gone from an initial curiosity to a now well-recognized phenomenon. This has demanded expansion of receptor theory models to account for multiple receptor states and a re-definition of ligand efficacy. However, after several decades of discovery, the clinical importance of inverse agonist ligands is still speculative because this work is… (More)

Cite this paper

@article{Parra2007InverseAF, title={Inverse agonism: from curiosity to accepted dogma, but is it clinically relevant?}, author={Sergio Parra and Richard A. Bond}, journal={Current opinion in pharmacology}, year={2007}, volume={7 2}, pages={146-50} }