Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIβ

  title={Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIβ},
  author={Hiroyuki Okuno and Kaori Akashi and Yuichiro Ishii and Nan Yagishita-Kyo and Kanzo Suzuki and Mio Nonaka and Takashi Kawashima and Hajime Fujii and Sayaka Takemoto-Kimura and Manabu Abe and Rie Natsume and Shoaib Chowdhury and Kenji Sakimura and Paul F Worley and Haruhiko Bito},
The Arc/Arg3.1 gene product is rapidly upregulated by strong synaptic activity and critically contributes to weakening synapses by promoting AMPA-R endocytosis. However, how activity-induced Arc is redistributed and determines the synapses to be weakened remains unclear. Here, we show targeting of Arc to inactive synapses via a high-affinity interaction with CaMKIIβ that is not bound to calmodulin. Synaptic Arc accumulates in inactive synapses that previously experienced strong activation and… CONTINUE READING
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