Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p 53 GeneMutations in Squamous Cell Carcinoma of the Head and Neck

@inproceedings{Westra2008InverseRB,
  title={Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p 53 GeneMutations in Squamous Cell Carcinoma of the Head and Neck},
  author={William H Westra and Janis M Taube and Maria Luana Poeta and Shanaz Begum and David Sidransky and andWayneM. Koch},
  year={2008}
}
Purpose: Squamous cell carcinomasof theheadandneck (HNSCC)oftenharborp53mutations, but p53 protein degradation by the viral oncoprotein E6may supercede p53 mutations in human papillomavirus 16 (HPV16)^ positive tumors. The prevalence of p53 mutations in HPV-positive HNSCCs is indeed lower, but in some tumors these alterations coexist.The purpose of this study was to discernwhetherHNSCCs differ in the type ofp53mutations as a functionofHPV16 status. Experimental Design: The study was nested… CONTINUE READING
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