Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients

@inproceedings{Qatanani2013InverseRO,
  title={Inverse Regulation of Inflammation and Mitochondrial Function in Adipose Tissue Defines Extreme Insulin Sensitivity in Morbidly Obese Patients},
  author={Mohammed Qatanani and Yejun Tan and R. S. Dobrin and Danielle M. Greenawalt and Guanghui Hu and Wenqing Zhao and Jerrold M. Olefsky and Dorothy D Sears and Lee M. Kaplan and Daniel M. Kemp},
  booktitle={Diabetes},
  year={2013}
}
Obesity is associated with insulin resistance, a major risk factor for type 2 diabetes and cardiovascular disease. However, not all obese individuals are insulin resistant, which confounds our understanding of the mechanistic link between these conditions. We conducted transcriptome analyses on 835 obese subjects with mean BMI of 48.8, on which we have previously reported genetic associations of gene expression. Here, we selected ~320 nondiabetic (HbA(1c) <7.0) subjects and further stratified… CONTINUE READING