Inverse Effects of Oxytocin on Attributing Mental Activity to Others in Depressed and Healthy Subjects: A Double-Blind Placebo Controlled fMRI Study

@inproceedings{Pincus2010InverseEO,
  title={Inverse Effects of Oxytocin on Attributing Mental Activity to Others in Depressed and Healthy Subjects: A Double-Blind Placebo Controlled fMRI Study},
  author={David Pincus and Samet Kose and Ashley B Arana and Kevin A. Johnson and Paul Simon Morgan and Jeffrey Borckardt and Tal Herbsman and Fran A Hardaway and Mark S. George and Jaak Panksepp and Ziad Nahas},
  booktitle={Front. Psychiatry},
  year={2010}
}
BACKGROUND Oxytocin is a stress-attenuating and pro-social neuropeptide. To date, no study has looked at the effects of oxytocin in modulating brain activity in depressed individuals nor attempted to correlate this activity with attribution of mental activity in others. METHOD We enrolled 10 unmedicated depressed adults and 10 matched healthy controls in a crossover, double blind placebo controlled fMRI 40 i.u. intra-nasal oxytocin study (20 i.u. per nostril). Each subject performed reading… CONTINUE READING

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