Inverse Agonist Properties of Antipsychotic Agents at Cloned, Human (h) Serotonin (5-HT)1B and h5-HT1D Receptors

@article{Audinot2001InverseAP,
  title={Inverse Agonist Properties of Antipsychotic Agents at Cloned, Human (h) Serotonin (5-HT)1B and h5-HT1D Receptors},
  author={Val{\'e}rie Audinot and Adrian Newman-Tancredi and Didier Cussac and Mark John Millan},
  journal={Neuropsychopharmacology},
  year={2001},
  volume={25},
  pages={410-422}
}
The actions of diverse antipsychotics at cloned h5-HT1B and h5-HT1D receptors were examined employing [3H]-GR125,743 and [35S]-GTPγS for determination of affinities and efficacies, respectively. Compared with hD2 receptors, haloperidol, chlorpromazine and olanzapine showed markedly (>100-fold) lower affinity for h5-HT1D and h5-HT1B receptors at which they expressed inverse agonist properties. Clozapine, risperidone and ocaperidone likewise behaved as inverse agonists at h5-HT1B and h5-HT1D… CONTINUE READING