Invasiveness of human glioma cell lines in vitro: Relation to tumorigenicity in athymic mice

@article{Ridder1987InvasivenessOH,
  title={Invasiveness of human glioma cell lines in vitro: Relation to tumorigenicity in athymic mice},
  author={Leo Isabelle De Ridder and Ole Didrik Laerum and Sverre Jarl M\ork and Darell D Bigner},
  journal={Acta Neuropathologica},
  year={1987},
  volume={72},
  pages={207-213}
}
Five established cell lines derived from human anaplastic astrocytomas or glioblastoma multiforme were tested for invasiveness into precultured chick heart fragments in vitro. Four of the cell lines (U118 MG, D54 MG, U373 MG and A172) were strongly invasive into the heart tissue. A fifth cell line, U251 MG sp, which was only tumorigenic at doses of greater than 1×108 cells in athymic mice, was non-invasive in vitro. One line, A172, was invasive but not tumorigenic in athymic mice, although a… CONTINUE READING