Invasiveness of breast cancer cells MDA-MB-231 through extracellular matrix is increased by the estradiol metabolite 4-hydroxyestradiol.

@article{Paquette2005InvasivenessOB,
  title={Invasiveness of breast cancer cells MDA-MB-231 through extracellular matrix is increased by the estradiol metabolite 4-hydroxyestradiol.},
  author={Benoit Paquette and M Sheldon Bisson and Catherine G Baptiste and H{\'e}l{\`e}ne Therriault and Rosalie Lemay and Andr{\'e} M. Cantin},
  journal={International journal of cancer},
  year={2005},
  volume={113 5},
  pages={706-11}
}
In malignant breast cancer, estrogen metabolism is altered, favoring the accumulation of hydroxyestradiols, which can generate free radicals. These reactive species can activate matrix metalloproteinases (MMPs), which in turn can hydrolyze the proteins of the extracellular matrix (ECM) that act as a barrier to tumor cell passage. The aim of this study was to determine whether reactive oxygen species generated by 4-hydroxyestradiol (4-OHE(2)) can activate MMP-2 and then enhance the invasiveness… CONTINUE READING

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