Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies

@inproceedings{Yu2010InvasiveLC,
  title={Invasive lobular carcinoma with extracellular mucin production and HER-2 overexpression: a case report and further case studies},
  author={Jing Yu and Rohit Bhargava and David J Dabbs},
  booktitle={Diagnostic pathology},
  year={2010}
}
Invasive lobular carcinomas (ILC) of breast typically demonstrate intracytoplasmic mucin. We present a unique case of classical type ILC with abundant extracellular mucin and strong ERBB2 (HER2/neu) expression confirmed by immunohistochemistry and fluorescent in situ hybridization. Dual E-cadherin/p120 immunohistochemical stain demonstrated complete loss of membranous E-cadherin and the presence of diffuse cytoplasmic p120 staining, confirming the lobular phenotype. The tumor cells showed… CONTINUE READING
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