Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?

@article{Guiu2014InvasiveLB,
  title={Invasive lobular breast cancer and its variants: how special are they for systemic therapy decisions?},
  author={S{\'e}v{\'e}rine Guiu and Anita Wolfer and William Jacot and Pierre Fumoleau and Gilles H Romieu and Franck Bonnetain and Maryse Fiche},
  journal={Critical reviews in oncology/hematology},
  year={2014},
  volume={92 3},
  pages={235-57}
}
The WHO classification of breast tumors distinguishes, besides invasive breast cancer 'of no special type' (former invasive ductal carcinoma, representing 60-70% of all breast cancers), 30 special types, of which invasive lobular carcinoma (ILC) is the most common (5-15%). We review the literature on (i) the specificity and heterogeneity of ILC biology as documented by various analytical techniques, including the results of molecular testing for risk of recurrence; (ii) the impact of lobular… CONTINUE READING
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