Invasive fungal infections in pediatric patients treated with tumor necrosis alpha (TNF‐α) inhibitors

@article{Tragiannidis2017InvasiveFI,
  title={Invasive fungal infections in pediatric patients treated with tumor necrosis alpha (TNF‐$\alpha$) inhibitors},
  author={Athanasios Tragiannidis and Ioannis Kyriakidis and Ilse Z{\"u}ndorf and Andreas H. Groll},
  journal={Mycoses},
  year={2017},
  volume={60}
}
Macromolecular immunosuppressive monoclonal antibodies and fusion proteins directed against molecules or cells involved in inflammation and immunity represent a recent and important addition to our therapeutic armamentarium. Tumor necrosis alpha (TNFα) is a cytokine involved in systemic inflammation and clinical utilization of its antagonists has revolutionized treatment of juvenile rheumatoid and psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, and plaque… 
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29 Citations
Background Citations
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29 Citations

Serious Opportunistic Lower Respiratory Tract Infections in Pediatric Rheumatic Diseases During Treatment With Biologics
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Children with rheumatic diseases with rather asymptomatic, serious opportunistic lower respiratory tract infections (LRTIs) during immunomodulatory treatment are reported, aiming to identify a correlation between inflammatory biomarkers and the development of the opportunistic LRTI.
Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies
TLDR
The current state of knowledge about infectious complications of biologic and small molecule immunomodulatory agents is reviewed to create a single resource relevant to a broad range of clinicians and researchers.
Pneumocystis jirovecii Pneumonia in Children with Hematological Malignancies: Diagnosis and Approaches to Management
TLDR
Immunofluorescence testing with monoclonal antibodies followed by fluorescent microscopy and polymerase chain reaction testing of respiratory specimens have emerged as the best diagnostic methods and measurement of (1-3)-β-D-glucan in the serum has a high negative predictive value in ruling out PJP.
Pathophysiological Concepts and Management of Pulmonary Manifestation of Pediatric Inflammatory Bowel Disease
TLDR
This review article summarizes the current knowledge about PM in pediatric IBD patients, focusing on pathophysiological and clinical aspects.
Epidemiology of Invasive Fungal Disease in Children
TLDR
This review focuses on fungal disease epidemiology with a specific emphasis on the 2 most common pediatric IFDs, IC and invasive aspergillosis (IA).
Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
TLDR
A significant number of OI is found in JIA patients on immunosuppressive therapy and the proposed list of Oi, created by consensus and validated in the Pharmachild cohort, could facilitate comparison among future pharmacovigilance studies.
Invasive Fungal Diseases in Children with Hematological Malignancies Treated with Therapies That Target Cell Surface Antigens: Monoclonal Antibodies, Immune Checkpoint Inhibitors and CAR T-Cell Therapies
TLDR
Although this new era of precision medicine shows promising outcomes of targeted therapies in children with leukemia or lymphoma, the results of this review stress the necessity for ongoing surveillance and suggest the need for antifungal prophylaxis in cases where IFDs are very common complications.
From mother to baby: antenatal exposure to monoclonal antibody biologics
TLDR
The potential risks of infections and reported hematological and immunological effects of antenatal mAbs exposure on the infant and guidance on the management of the exposed infant are described.
A mechanistic perspective, clinical applications, and phage-display-assisted discovery of TNFα inhibitors.
Immune Response in Pneumocystis Infections According to the Host Immune System Status
TLDR
The immune response associated with a favourable outcome of the infection may differ according to the immune status of the host, and a close communication between B cells and TCD4 within tertiary lymphocyte structures appears critical to activate M2 macrophages without much inflammation.
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