Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases.

@article{Inamoto2007InvasiveAO,
  title={Invasive ability of human renal cell carcinoma cell line Caki-2 is accelerated by gamma-aminobutyric acid, via sustained activation of ERK1/2 inducible matrix metalloproteinases.},
  author={Teruo Inamoto and Haruhito Azuma and Takeshi Sakamoto and Satoshi Kiyama and Takanobu Ubai and Yatsugu Kotake and Masahito Watanabe and Yoji Katsuoka},
  journal={Cancer investigation},
  year={2007},
  volume={25 7},
  pages={574-83}
}
Gamma-aminobutyric acid (GABA) was first discovered as an inhibitory neurotransmitter in the central nervous system (CNS) and has been reported to have a variety of functions, including regulation of cell division, cell differentiation and maturation, and to be involved in the development of certain cancers outside the CNS. In the present study, using the human renal cell carcinoma cell line Caki-2, we demonstrated that GABA stimulation significantly increased the expression of MMP-2 and -9 and… CONTINUE READING
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