Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease

@inproceedings{Vu2014InvasionOT,
  title={Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease},
  author={Kiem Vu and Rick C Tham and John P Uhrig and George R Thompson and Sarisa Na Pombejra and Mantana Jamklang and Jennifer M Bautos and Angie Gelli},
  booktitle={mBio},
  year={2014}
}
UNLABELLED Cryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system. Why Cryptococcus neoformans has this remarkable tropism for the CNS is not clear. Recent research on cerebral pathogenesis of C. neoformans revealed a predominantly transcellular migration of cryptococci across the brain endothelium; however, the identities of key fungal virulence factors that function specifically to invade the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

Cryptococcal Traits Mediating Adherence to Biotic and Abiotic Surfaces

  • Journal of fungi
  • 2018
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia.

  • The Journal of infectious diseases
  • 2002
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL