Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis.

@article{Chukkapalli2014InvasionOO,
  title={Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis.},
  author={Sasanka S. Chukkapalli and Mercedes F. Rivera and Irina M. Velsko and Juyoun Lee and Hao Chen and Donghang Zheng and Indraneel B Bhattacharyya and Pandu R. R. Gangula and Alexandra R Lucas and Lakshmyya N. Kesavalu},
  journal={Infection and immunity},
  year={2014},
  volume={82 5},
  pages={1959-67}
}
Treponema denticola is a predominantly subgingival oral spirochete closely associated with periodontal disease and has been detected in atherosclerosis. This study was designed to evaluate causative links between periodontal disease induced by chronic oral T. denticola infection and atherosclerosis in hyperlipidemic ApoE(-/-) mice. ApoE(-/-) mice (n = 24) were orally infected with T. denticola ATCC 35404 and were euthanized after 12 and 24 weeks. T. denticola genomic DNA was detected in oral… CONTINUE READING
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