Invasion of Trypanosoma cruzi into host cells is impaired by N-propionylmannosamine and other N-acylmannosamines

@article{Lieke2010InvasionOT,
  title={Invasion of Trypanosoma cruzi into host cells is impaired by N-propionylmannosamine and other N-acylmannosamines},
  author={Thorsten Lieke and Daniel Gr{\"o}be and V{\'e}ronique Blanchard and Detlef Grunow and Rudolf Tauber and Martin Zimmermann-Kordmann and Thomas Jacobs and Werner Reutter},
  journal={Glycoconjugate Journal},
  year={2010},
  volume={28},
  pages={31-37}
}
The etiologic agent of Chagas’ disease, Trypanosoma cruzi, is widely distributed in South America, affecting millions of people with thousands of deaths every year. Adherence of the infectious trypomastigote to host cells is mediated by sialic acid. T. cruzi cannot synthesize sialic acids on their own but cleave them from the host cells and link them to glycans on the surface of the parasites using the trans-sialidase, a GPI-anchored enzyme. The infectivity of the protozoan parasites strongly… 

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