Invasion marker PAI‐1 remains a strong prognostic factor after long‐term follow‐up both for primary breast cancer and following first relapse

@article{Harbeck1999InvasionMP,
  title={Invasion marker PAI‐1 remains a strong prognostic factor after long‐term follow‐up both for primary breast cancer and following first relapse},
  author={Nadia Harbeck and Christoph Thomssen and Ursula Berger and K. Ulm and Ronald E. Kates and Heinz Hoefler and F. J{\"a}nicke and Henner Graeff and Manfred Schmitt},
  journal={Breast Cancer Research and Treatment},
  year={1999},
  volume={54},
  pages={147-157}
}
In 1991, our group was the first to report the prognostic strength of plasminogen activator inhibitor type 1 (PAI‐1) in primary breast cancer. The prognostic impact of invasion markers PAI‐1 and urokinase‐type plasminogen activator (uPA) on disease‐free survival (DFS) and overall survival (OS) in breast cancer has since been independently confirmed. We now report on the prognostic impact of PAI‐1 and uPA after long‐term median follow‐up of 77 months for our cohort (n=316). Levels of uPA, PAI‐1… CONTINUE READING