Invasion factors of apicomplexan parasites: essential or redundant?

  title={Invasion factors of apicomplexan parasites: essential or redundant?},
  author={Markus Meissner and David J. P. Ferguson and Friedrich Frischknecht},
  journal={Current opinion in microbiology},
  volume={16 4},
Apicomplexa are obligate intracellular parasites that cause several human and veterinary diseases worldwide. In contrast to most intracellular pathogens these protozoans are believed to invade a rather passive host cell in a process, that is, tightly linked to the ability of the parasites to move by gliding motility. Indeed specific inhibitors against components of the gliding machinery and the analysis of knockdown mutants demonstrate a linkage of gliding motility and invasion. Intriguingly… CONTINUE READING