Invasion and replication of Salmonella typhimurium in animal cells.

@article{Gahring1990InvasionAR,
  title={Invasion and replication of Salmonella typhimurium in animal cells.},
  author={Lorise C Gahring and Fred Heffron and Brett B. Finlay and Stanley Falkow},
  journal={Infection and immunity},
  year={1990},
  volume={58 2},
  pages={443-8}
}
A total of 81 avirulent Tn10 insertion mutants of Salmonella typhimurium have previously been described. These mutants were selected for the inability to survive in murine macrophages. We have characterized the abilities of the most avirulent of these mutants to adhere to, invade, and replicate in both macrophages and nonphagocytic epithelial cells. The results suggest that most mutants contain a defect that is specific to survival within professional phagocytes. These mutants invaded and… CONTINUE READING
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Advanced bacterial genetics

  • R. W. Davis, D. Botstein, J. R. Roth
  • Cold Spring Harbor Laboratory,
  • 1980

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