Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin.

Abstract

Invasion by colorectal carcinomas is characterized by an epithelial-mesenchymal transition (EMT)-like dedifferentiation of the tumor cells. However, a redifferentiation towards an epithelial phenotype, resembling a mesenchymal-epithelial transition, is detectable in metastases. This indicates that malignant progression is based on dynamic processes, which… (More)

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Cite this paper

@article{Brabletz2005InvasionAM, title={Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin.}, author={Thomas Brabletz and Falk Hlubek and Simone Spaderna and Otto Schmalhofer and Elke Hiendlmeyer and Andreas Jung and Thomas Kirchner}, journal={Cells, tissues, organs}, year={2005}, volume={179 1-2}, pages={56-65} }